Synthetic strategies for the construction of enantiomeric azanoradamantanes
作者： Daniel P. Becker , Roger Nosal , Daniel L. Zabrowski , Daniel L. Flynn
DOI: 10.1016/S0040-4020(96)00973-8
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摘要: Abstract The amino azanoradamantane hexahydro-2,5b-methano-IH-3aS,3aa,6aa-cyclopenta-[clpyrrole-4a-amine 1 and the corresponding enantiomer ent-1 have been prepared along with benzamide derivatives SC-52491 SC-52490, respectively, which are of pharmaceutical interest. key meso-azabicyclo[3.3.0] intermediate 3 was via three separate routes: a [3+2] cycloaddition route, radical cyclization/ionic cyclization reductive Pauson-Khand route.
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