Self-Administered Antibiotic Therapy for Chemotherapy-Induced, Low-Risk Febrile Neutropenia in Patients with Nonhematologic Neoplasms

摘要: A multicenter prospective nonrandomized trial was conducted to evaluate the efficacy of self-administered oral ofloxacin in treatment cancer patients with fever and neutropenia. Patients receiving chemotherapy who either resided far away were unable reach oncology ward within 12 hours onset or afford expensive inpatient care eligible for inclusion study. Requirements enrollment included an absolute neutrophil count ≤0.5×10 9 /L, a temperature >38 o C, ability take medications. The instructed immediately self-administer on recognition maintain daily telephonic contact staff. One-hundred eleven such episodes evaluable