High expression levels of nuclear factor κB, IκB kinase α and Akt kinase in squamous cell carcinoma of the oral cavity
作者： Hideki Nakayama , Tetsuro Ikebe , Mahiro Beppu , Kanemitsu Shirasuna
DOI: 10.1002/1097-0142(20011215)92:12<3037::AID-CNCR10171>3.0.CO;2-#
关键词:
摘要: BACKGROUND It has been reported that the transcription factor nuclear κB (NF-κB) is involved in growth, invasion, and antiapoptotic activity of cultured tumor cells. METHODS The authors used immunohistochemistry to examine expression NF-κB signaling molecules leading activation 36 untreated biopsy specimens from patients with squamous cell carcinoma (SCC) 15 epithelial dysplasia oral cavity. RESULTS Among examined, p65 subunit (p65) IκB kinase α (IKKα) were expressed highly almost all SCC whereas samples normal epithelia adjacent tumors as well negative for immunohistochemical staining. The invasiveness metastasis seemed correlate degree staining molecules. Moreover, phosphorylated Akt kinase, which may be associated antiapoptosis NF-κB, was detected same areas where IKKα existed large amounts. CONCLUSIONS The results suggest high levels contribute malignant behavior epithelium. Cancer 2001;92:3037–44. © 2001 American Society.
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