作者: Xue Yang , Ji Yang , Yiwei Chu , Yu Xue , Dandan Xuan
DOI: 10.1371/JOURNAL.PONE.0088441
关键词:
摘要: T follicular helper (Tfh) cells aid effector B cells, and augment autoimmunity, whereas the role of Tfh on regulatory (Breg) in systemic lupus erythematosus (SLE) is not known. The aim this study to investigate percentage Breg SLE, cells. First, we demonstrated presence SLE peripheral blood mononuclear involved skins. Both circulating ability produce interleukin-10 (IL-10) were elevated patients. increased during flares decreased following disease remission. Second, cell expansion was only related autoantibody production but also correlated with Third, vitro studies revealed that cell-derived IL-21 could promote IL-10 differentiation. In conclusions, these data imply may be linked are a feedback manner. Thus, development associated complex regulation diverse subsets.