T Follicular Helper Cells and Regulatory B Cells Dynamics in Systemic Lupus Erythematosus

作者: Xue Yang , Ji Yang , Yiwei Chu , Yu Xue , Dandan Xuan

DOI: 10.1371/JOURNAL.PONE.0088441

关键词:

摘要: T follicular helper (Tfh) cells aid effector B cells, and augment autoimmunity, whereas the role of Tfh on regulatory (Breg) in systemic lupus erythematosus (SLE) is not known. The aim this study to investigate percentage Breg SLE, cells. First, we demonstrated presence SLE peripheral blood mononuclear involved skins. Both circulating ability produce interleukin-10 (IL-10) were elevated patients. increased during flares decreased following disease remission. Second, cell expansion was only related autoantibody production but also correlated with Third, vitro studies revealed that cell-derived IL-21 could promote IL-10 differentiation. In conclusions, these data imply may be linked are a feedback manner. Thus, development associated complex regulation diverse subsets.

参考文章(38)
Feng Sun, Shafeeq S. Ladha, Li Yang, Qiang Liu, Samuel Xiang‐Yu Shi, Ning Su, Roberto Bomprezzi, Fu‐Dong Shi, Interleukin-10 producing-B cells and their association with responsiveness to rituximab in myasthenia gravis Muscle & Nerve. ,vol. 49, pp. 487- 494 ,(2014) , 10.1002/MUS.23951
Koichi Yanaba, Jean-David Bouaziz, Takashi Matsushita, Takeshi Tsubata, Thomas F. Tedder, The Development and Function of Regulatory B Cells Expressing IL-10 (B10 Cells) Requires Antigen Receptor Diversity and TLR Signals Journal of Immunology. ,vol. 182, pp. 7459- 7472 ,(2009) , 10.4049/JIMMUNOL.0900270
Paul A. Blair, Karina A. Chavez-Rueda, Jamie G. Evans, Mark J. Shlomchik, Ayad Eddaoudi, David A. Isenberg, Michael R. Ehrenstein, Claudia Mauri, Selective Targeting of B Cells with Agonistic Anti-CD40 Is an Efficacious Strategy for the Generation of Induced Regulatory T2-Like B Cells and for the Suppression of Lupus in MRL/ lpr Mice Journal of Immunology. ,vol. 182, pp. 3492- 3502 ,(2009) , 10.4049/JIMMUNOL.0803052
Rosanne Spolski, Hyoung-Pyo Kim, Wei Zhu, David E. Levy, Warren J. Leonard, IL-21 Mediates Suppressive Effects via Its Induction of IL-10 Journal of Immunology. ,vol. 182, pp. 2859- 2867 ,(2009) , 10.4049/JIMMUNOL.0802978
Bo Yu, Ming Guan, Yinghui Peng, Yong Shao, Chao Zhang, Xupeng Yue, Jie Zhang, Hong Yang, Hejian Zou, Wencai Ye, Jun Wan, Wei Zhang, Copy number variations of interleukin-17F, interleukin-21, and interleukin-22 are associated with systemic lupus erythematosus. Arthritis & Rheumatism. ,vol. 63, pp. 3487- 3492 ,(2011) , 10.1002/ART.30595
M R Amel Kashipaz, M L Huggins, P Lanyon, A Robins, R J Powell, I Todd, Assessment of Be1 and Be2 cells in systemic lupus erythematosus indicates elevated interleukin-10 producing CD5+ B cells. Lupus. ,vol. 12, pp. 356- 363 ,(2003) , 10.1191/0961203303LU338OA
Roza I. Nurieva, Yeonseok Chung, Daehee Hwang, Xuexian O. Yang, Hong Soon Kang, Li Ma, Yi-hong Wang, Stephanie S. Watowich, Anton M. Jetten, Qiang Tian, Chen Dong, Generation of T Follicular Helper Cells Is Mediated by Interleukin-21 but Independent of T Helper 1, 2, or 17 Cell Lineages Immunity. ,vol. 29, pp. 138- 149 ,(2008) , 10.1016/J.IMMUNI.2008.05.009
Luciën E. P. M. van der Vlugt, Lucja A. Labuda, Arifa Ozir-Fazalalikhan, Ellen Lievers, Anouk K. Gloudemans, Kit-Yeng Liu, Tom A. Barr, Tim Sparwasser, Louis Boon, Ulysse Ateba Ngoa, Eliane Ngoune Feugap, Ayola A. Adegnika, Peter G. Kremsner, David Gray, Maria Yazdanbakhsh, Hermelijn H. Smits, Schistosomes Induce Regulatory Features in Human and Mouse CD1dhi B Cells: Inhibition of Allergic Inflammation by IL-10 and Regulatory T Cells PLoS ONE. ,vol. 7, pp. e30883- ,(2012) , 10.1371/JOURNAL.PONE.0030883
Katja Brandt, Silvia Bulfone-Paus, Donald C. Foster, René Rückert, Interleukin-21 inhibits dendritic cell activation and maturation Blood. ,vol. 102, pp. 4090- 4098 ,(2003) , 10.1182/BLOOD-2003-03-0669
Robin A. Herlands, Sean R. Christensen, Rebecca A. Sweet, Uri Hershberg, Mark J. Shlomchik, T Cell-Independent and Toll-like Receptor-Dependent Antigen-Driven Activation of Autoreactive B Cells Immunity. ,vol. 29, pp. 249- 260 ,(2008) , 10.1016/J.IMMUNI.2008.06.009