Effect of GBA Mutations on Phenotype of Parkinson's Disease: A Study on Chinese Population and a Meta-Analysis

摘要: GBA has been identified as a genetic risk factor for PD. Whether the clinical manifestations of PD patients with or without mutations are different still not reached consensus. We firstly detected mutation L444P in 1147 Chinese and simultaneously evaluated their corresponding data. Then we compared phenotypes between 646 10344 worldwide through meta-analysis. Through method meta-analysis, there was significant difference age at onset (MD = -3.10 [95% CI: -4.88, -1.32]), bradykinesia an initial symptom (OR 1.49 1.15, 1.94]), having family history 1.50 1.18, 1.91]), dementia 3.21 1.97, 5.24]) during comparison mutations. While, aspect tremor 0.81 0.64, 1.03]), severity motor symptoms such H-Y 0.06 -0.06, 0.17]) UPDRS-III 1.61 -0.65, 3.87]) dyskinesia 1.60 0.90, 2.84]) two groups revealed no statistical differences. Our results suggested that from noncarriers.