Transforming growth factor beta 2 in epithelial differentiation of developing teeth and odontogenic tumors.

摘要: Dysregulation of TGF beta 2, a modulator cell growth and differentiation, can result in uncontrolled tumor formation. Our comparative studies on the expression 2 mRNA protein indicate that may primarily be regulator epithelial differentiation during tooth development (between 13 20 gestational wk) tumorigenesis odontogenic neoplasms. A paracrine mode action for early human germ (cap/early bell stage) is suggested by location mesenchyme surrounding germ, whereas found dental lamina enamel organ. During late stage, gene shifted from to epithelium was colocalized with protein, suggesting an autocrine role terminal ameloblasts. In tumors origin (ameloblastomas) epithelial-ectomesencymal (ameloblastic fibromas), mostly located mesenchymal component component. Odontogenic ectomesenchymal (myxomas) were not associated expression. The results imply play important epithelial-mesenchymal interactions morphogenesis tumors.