Hypoxia-induced pulmonary vascular remodeling: a model for what human disease?

摘要: Exposure of most animals to low levels environmental oxygen results in alveolar hypoxia and reliably causes chronic pulmonary hypertension morphological alterations the precapillary vessels (1–4). Chronic hypoxic exposure has been used for decades induce vascular remodeling and, more recently, assess roles this process lipid mediators (5), endothelin (6), serotonin (7), nitric oxide (NO) (8, 9), prostacyclin (10), as well VEGF its receptors (11, 12). As one measure clinical importance work system, trials are now ongoing test receptor blockers treatment severe hypertension.