Diverse approaches for the enhancement of oral drug bioavailability.
作者： Pius Fasinu , Viness Pillay , Valence M. K. Ndesendo , Lisa C. du Toit , Yahya E. Choonara
DOI: 10.1002/BDD.750
关键词:
摘要: … Published results on structurally diverse drugs have shown that the inter-subject variability in bioavailability is higher with poorly bioavailable drugs 8. Therefore, low oral bioavailability …
sci-hub.se 参考文章(158)
Valérie F. Cosson, Eliane Fuseau, Mixed Effect Modeling of Sumatriptan Pharmacokinetics During Drug Development: II. From Healthy Subjects to Phase 2 Dose Ranging in Patients Journal of Pharmacokinetics and Biopharmaceutics. ,vol. 27, pp. 149- 171 ,(1999) , 10.1023/A:1020601906027
Arati A. Deshpande, Navnit H. Shah, Christopher T. Rhodes, Waseem Malick, Development of a Novel Controlled-Release System for Gastric Retention Pharmaceutical Research. ,vol. 14, pp. 815- 819 ,(1997) , 10.1023/A:1012171010492
Ina Bergheim, Christiane Bode, Alexandr Parlesak, Distribution of cytochrome P450 2C, 2E1, 3A4, and 3A5 in human colon mucosa BMC Clinical Pharmacology. ,vol. 5, pp. 4- 4 ,(2005) , 10.1186/1472-6904-5-4
J A Terrell, E H Ulm, K S Pang, W F Cherry, Disposition of enalapril and its diacid metabolite, enalaprilat, in a perfused rat liver preparation. Presence of a diffusional barrier for enalaprilat into hepatocytes. Drug Metabolism and Disposition. ,vol. 12, pp. 309- 313 ,(1984)
Paul Glue, Robert P. Clement, Cytochrome P450 enzymes and drug metabolism--basic concepts and methods of assessment. Cellular and Molecular Neurobiology. ,vol. 19, pp. 309- 323 ,(1999) , 10.1023/A:1006993631057
A.H. Schinkel, S. Kemp, M. Dollé, G. Rudenko, E. Wagenaar, N-glycosylation and deletion mutants of the human MDR1 P-glycoprotein Journal of Biological Chemistry. ,vol. 268, pp. 7474- 7481 ,(1993) , 10.1016/S0021-9258(18)53199-9
M K Chourasia, S K Jain, Pharmaceutical approaches to colon targeted drug delivery systems. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences. ,vol. 6, pp. 33- 66 ,(2003)
Yuichi Sugiyama, Hiroshi Suzuki, Charles L. Crespi, Kiyomi Ito, Iichiro Kawahara, Meguru Achira, Yukio Kato, Selective Inhibition of Human Cytochrome P450 3A4 byN-[2(R)-Hydroxy-1(S)-indanyl]-5-[2(S)-(1,1-dimethylethylaminocarbonyl)-4-[(furo[2,3-b]pyridin-5-yl)methyl]piperazin-1-yl]-4(S)-hydroxy-2(R)-phenylmethylpentanamide and P-glycoprotein by Valspodar in Gene Transfectant Systems Drug Metabolism and Disposition. ,vol. 28, pp. 1238- 1243 ,(2000)
Thomas R Ziegler, Concepción Fernández-Estívariz, Li H Gu, Niloofar Bazargan, Kay Umeakunne, Timothy M Wallace, Emma E Diaz, Kathia E Rosado, Robert R Pascal, John R Galloway, Josiah N Wilcox, Lorraine M Leader, Distribution of the H+/peptide transporter PepT1 in human intestine: up-regulated expression in the colonic mucosa of patients with short-bowel syndrome The American Journal of Clinical Nutrition. ,vol. 75, pp. 922- 930 ,(2002) , 10.1093/AJCN/75.5.922
Mary Vore, Tim Hoffman, Lothar Jennes, Aldo D. Mottino, Expression and Localization of Multidrug Resistant Protein mrp2 in Rat Small Intestine Journal of Pharmacology and Experimental Therapeutics. ,vol. 293, pp. 717- 723 ,(2000)