ABC transporters and their role in nucleoside and nucleotide drug resistance.

摘要: ATP-binding cassette (ABC) transporters confer drug resistance against a wide range of chemotherapeutic agents, including nucleoside and nucleotide based drugs. While drugs have been used for many years in the treatment solid hematological malignancies as well viral autoimmune diseases, potential contribution ABC has only recently recognized. This neglect is likely because activation derivatives require an initial carrier-mediated uptake step followed by phosphorylation kinases, defects or kinase were considered primary mechanisms resistance. However, recent studies demonstrate that members ABCC transporter subfamily reduce intracellular concentration monophosphorylated In addition to members, ABCG2 shown transport nucleoside-monophosphate clinically relevant such cytarabine, cladribine, clofarabine name few. review will discuss how they interact with other processes affecting efficacy