Phosphine-mediated MBH-Type/Acyl transfer/wittig sequence for construction of functionalized furo[3,2-c]coumarins
作者： Wenwei Lin , Sandip Sambhaji Vagh , Athukuri Edukondalu , Pin Ching Wang , Bo Jhih Hou
DOI: 10.1021/ACS.ORGLETT.0C04082
关键词:
摘要: A new method for the construction of functionalized furo[3,2-c]coumarins via MBH-type/acyl-transfer/Wittig reaction is reported. The current approach would open a route simultaneous formation two rings in one-pot which accompanied by incorporation keto functionality on furan ring activating terminal alkynoates with phosphine. Furthermore, this protocol could also be applicable to internal alkynoates/propiolamides generate 2,3-disubstituted furo[3,2-c]coumarins/furo[3,2-c]quinolinones excluding acyl-transfer reaction.
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