Acute physical and psychological stress effects on visceral hypersensitivity in male rat: role of central nucleus of the amygdala

摘要: Objective The aim of this study was to investigate the effects acute physical and psychological stress temporary central nucleus amygdala (CeA) block on stress-induced visceral hypersensitivity. Methods Forty two male Wistar rats were used in study. Animals divided into 7 groups (n = 6); 1 – Control, 2 stress, 3 4 sham, 5 lidocaine, 6 lidocaine + physical lidocaine + psychological stress. Stress induction done using a communication box. Results Abdominal withdrawal reflex (AWR) score monitored one hour after exposure. AWR significantly heightened at 20, 40 60 mmHg group compared with control (p < 0.05), while, it almost unchanged other groups. This strikingly decreased no tangible response Total stool weight increased (0.72 ± 0.15, 0.1 ± 0.06 g) but did not change (0.16 ± 0.12, (p < 0.05). Concomitant use lidocaine followed same results (0.18 ± 0.2, 0.72 ± 0.15 g) while have any effect (0.25 ± 0.1, 0.16 ± 0.12 g) (p < 0.05). Conclusions Psychological could strongly affect hypersensitivity. is statistically comparable Temporary CeA also reduce hypersensitivity post-acute