Mechanisms of Ventricular Fibrillation in Canine Models of Congestive Heart Failure and Ischemia Assessed by In Vivo Noncontact Mapping

摘要: Background— Much of the research performed studying mechanism ventricular fibrillation (VF) has been in normal ventricles rather than under a pathological condition predisposing to VF. We hypothesized that different substrates would alter and characteristics Methods Results— Three groups dogs were studied: (1) control (n=8), (2) pacing-induced congestive heart failure (n=7), (3) acute ischemia produced by 30 minutes mid left anterior descending artery ligation (n=5). A noncontact mapping catheter (Ensite 3000, ESI) was placed via transseptal into ventricle (LV), along with an electrophysiology catheter. multielectrode basket (EP Technologies) right ventricle, Several episodes VF recorded each animal. In addition constructing isopotential isochronal maps episodes, signals underwent frequency domain analysis as fast Fourier transform performe...