The pruritus of cholestasis.

摘要: Why do patients with cholestasis itch? The answer to this fundamental question is unknown. It inferred that substances accumulate in plasma and other tissues, as a result of cholestasis, cause pruritus; however, the specific nature mechanism by which they pruritus has not been discerned. absence clear rationale studies lack techniques study human beings, specifically, have contributed vacuum information on pathophysiology pathogenesis cholestasis. Over past 15 years, progress made advancing philosophy research pruritus, like any type scientific area, requires valid methodology provides objective data be analyzed. In context, development system allows for conduct behavioral scratching activity, manifestation sensation itch, satisfied requirement methodology. With use technique, role endogenous opioid demonstrated.