Mammaglobin expression in lymph nodes is an important marker of metastatic breast carcinoma.
作者： Ha-Chul Shin , Yup Kang , Young-Bae Kim , Hyun-Soo Kim , Jae-Ho Han
DOI: 10.1043/1543-2165(2003)127<1330:MEILNI>2.0.CO;2
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摘要: Abstract Context.—Organ specificity is a desirable property of tumor marker, especially in metastatic adenocarcinomas unknown primary origin. Mammaglobin, mammary-specific member the uteroglobin family, known to be overexpressed human breast cancer. Objective.—We investigated mammaglobin A expression carcinomas lymph nodes from and various other organs its usefulness identifying carcinoma breast. For comparative purposes, we also BRST-1 BRST-2 expression. Design.—We produced recombinant polyclonal antimammaglobin antibodies. Mammaglobin was analyzed by immunohistochemical staining using tissue microarray reverse transcription–polymerase chain reaction 210 carcinomas, including those (n = 70), lung 30), stomach colorectum 25), hepatobiliary tract 20), urinary 10), thyroid gland ovary endometrium salivary gl...
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