Hepatitis C virus infection in the mothers and infants cohort study.

摘要: Objectives. To estimate the hepatitis C virus (HCV) vertical transmission rate, effect of potential risk factors, and pattern HCV antibody response viremia in HCV-infected infants. Study Design. The Mothers Infants Cohort enrolled both human immunodeficiency (HIV)-seropositive HIV-seronegative pregnant women at five obstetric clinics New York City a prospective cohort study between January 1986 1991. mothers their 122 offspring were followed-up for minimum 12 months evidence infection as determined by persistent antibodies or detection RNA reverse transcription polymerase chain reaction. Comparisons among groups categorical variables performed using Fisher9s exact test. Results. Seven (6%; 95% confidence interval, 2%-11%) infants HCV-infected. There was tendency increased with maternal viral obstetrical such coinfection HIV (7% vs 4%), high load (13% 6%), (8% 3%), vaginal delivery (6% 0%), female gender although none associations reached statistical significance. After loss antibody, seroconversion occurred mean age 26 3 HIV-coinfected compared 7 4 HIV-uninfected Serial samples showed that persisted 6 least 18 to 54 months. Conclusions. Our is accordance other studies have shown low overall trend toward higher factors HIV-coinfection viremia. A delay infant may be associated larger are needed confirm these findings.