The kinetics of tritium-hydrogen exchange between xanthine, theophylline,caffeine and water
作者： MaŁgorzata Jelińska , Jerzy Sobkowski
DOI: 10.1016/0040-4020(77)80196-8
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摘要: Abstract Isotopic hydrogen exchange at C-8 of xanthine, theophylline and caffeine in water has been studied several temperatures constant pH. The rates detritiation these compounds have determined over a pH range temperature. rate-pH profiles for are interpreted terms rate determining attack by hydroxide ion on protonated substrate. For xanthine high an additional mechanism involving catalysed the neutral compound is suggested.
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