Reciprocal Interactions between Commensal Bacteria and γδ Intraepithelial Lymphocytes during Mucosal Injury
作者： Anisa S. Ismail , Cassie L. Behrendt , Lora V. Hooper
关键词:
摘要: The intestinal mucosal surface is in direct contact with a vast beneficial microbiota. symbiotic nature of this relationship threatened when the epithelium injured, yet little known about how surfaces maintain homeostasis commensal microbes following damage. γδ Intraepithelial lymphocytes (γδ IEL) reside at gut epithelial surface, where they stimulate healing acute injury. A genome-wide analysis IEL response to dextran sulfate sodium-induced colonic damage revealed induction complex transcriptional program, including coordinate regulation cytoprotective, immunomodulatory, and antibacterial factors. Studies germfree mice demonstrated that microbiota regulate key components thus revealing dialogue between bacteria injured epithelia. Analysis TCRδ-deficient indicated T cells are essential for controlling penetration immediately damage, suggesting function host-microbial Taken together, these findings disclose reciprocal promotes relationships intestine.
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