Toxicity of 3,4,5,3?,4?,5?-hexachlorobiphenyl to mink
作者： R. J. Aulerich , S. J. Bursian , M. G. Evans , J. R. Hochstein , K. A. Koudele
DOI: 10.1007/BF01055359
关键词:
摘要: Diets supplemented with 0.01 or 0.05 ppm (mg/kg) of 3,4,5,3′,4′,5′-hexachlorobiphenyl (345-HCB) were fed to mink investigate the toxicological manifestations this toxic polychlorinated biphenyl congener in a sensitive species. Dietary exposure for 135 days resulted 50% mortality while no deaths occurred on 345-HCB. Clinical signs toxicity included anorexia, bloody stools, disrupted molting patterns, and thickened, elongated deformed nails. Ascites gastric ulcers present animals that died. Statistically significant increases liver, kidney, adrenal gland weights found 345-HCB-treated mink. Decreases total free triiodothyronine concentrations observed diets thyroxine was decreased No consistent histopathologic lesions thyroid glands mink, nor there any statistically differences between control serum epidermal growth factor levels, plasma 17β-estradiol progesterone concentrations, hepatic aminopyrine N-demethylase, benzo(α)pyrene hydroxylase activities, hypothalamic norepinephrine, dopamine, serotonin incorporation (3H) thymidine by concanavalin-A-stimulated lymphocytes.
springer.com
sci-hub.se 参考文章(39)
S. Safe, A. Parkinson, L. Robertson, R. Cockerline, L. Safe, PCBs AS MICROSOMAL ENZYME INDUCERS: STRUCTURE-ACTIVITY RULES Toxicology of Halogenated Hydrocarbons#R##N#Health and Ecological Effects. pp. 106- 119 ,(1981) , 10.1016/B978-0-08-027530-7.50014-5
Michael R. Bleavins, Richard J. Aulerich, Immunotoxicologic effects of polychlorinated biphenyls on the cell-mediated and humoral immune systems. Residue reviews. ,vol. 90, pp. 57- 67 ,(1983) , 10.1007/978-1-4612-5606-9_3
GPM Moore, BA Panaretto, D Robertson, Inhibition of wool growth in merino sheep following administration of mouse epidermal growth factor and a derivative. Australian Journal of Biological Sciences. ,vol. 35, pp. 163- 172 ,(1982) , 10.1071/BI9820163
Richard J. Aulerich, Michael R. Bleavins, Robert K. Ringer, Thomas G. Bell, Excessive nail growth in the European ferret induced by Aroclor 1242. Archives of Environmental Contamination and Toxicology. ,vol. 11, pp. 305- 312 ,(1982) , 10.1007/BF01055207
R.K. Ringer, R.J. Aulerich, M.R. Bleavins, BIOLOGICAL EFFECTS OF PCBs AND PBBs ON MINK AND FERRETS - A REVIEW Toxicology of Halogenated Hydrocarbons#R##N#Health and Ecological Effects. pp. 329- 343 ,(1981) , 10.1016/B978-0-08-027530-7.50030-3
E. M. Convey, T. W. Beck, R. R. Neitzel, E. F. Bostwick, H. D. Hafs, Negative feedback control of bovine serum luteinizing hormone (LH) concentration from completion of the preovulatory LH surge until resumption of luteal function. Journal of Animal Science. ,vol. 45, pp. 792- 796 ,(1977) , 10.2527/JAS1977.454792X
B. J. Gerloff, T. H. Herdt, W. W. Wells, R. F. Nachreiner, R. S. Emery, Inositol and Hepatic Lipidosis. II. Effect of Inositol Supplementation and Time from Parturition on Serum Insulin, Thyroxine and Triiodothyronine and Their Relationship to Serum and Liver Lipids in Dairy Cows Journal of Animal Science. ,vol. 62, pp. 1693- 1702 ,(1986) , 10.2527/JAS1986.6261693X
Richard J. Aulerich, Michael R. Bleavins, Barbara A. Olson, Lee R. Shull, Polychlorinated biphenyls (Aroclors ® 1016 and 1242): Effect on hepatic microsomal mixed function oxidases in mink and ferrets Archives of Environmental Contamination and Toxicology. ,vol. 11, pp. 313- 321 ,(1982) , 10.1007/BF01055208
Karl Rozman, George A. Hazelton, Curtis D. Klaassen, Michael P. Arlotto, Andrew Parkinson, Effect of thyroid hormones on liver microsomal enzyme induction in rats exposed to 2,3,7,8,-tetra-chlorodibenzo-p-dioxin Toxicology. ,vol. 37, pp. 51- 63 ,(1985) , 10.1016/0300-483X(85)90112-X
Mark D. Seefeld, Stephen W. Corbett, Richard E. Keesey, Richard E. Peterson, Characterization of the wasting syndrome in rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicology and Applied Pharmacology. ,vol. 73, pp. 311- 322 ,(1984) , 10.1016/0041-008X(84)90337-5