Farnesoid X Receptor (FXR) from normal to malignant state

摘要: The Farnesoid X Receptor (FXR) is a member of the nuclear receptor superfamily ligand-activated transcription factors, which plays crucial role in bile acid, cholesterol, lipid and glucose metabolism, as well development atherosclerosis, intestinal bacterial growth liver regeneration. FXR also involved pathogenesis cholestatic diseases, non-alcoholic fatty disease inflammatory bowel disease. Recent evidence further suggests key for apoptosis cancer. Notably, deficiency promoted inflammation tumorigenesis, suggesting that activation might be promising strategy treatment colon mice led to spontaneous hepatocarcinomas, while inhibition represent novel therapeutic approach Barett's esophagus. In breast cancer cell lines, agonists down-regulated target gene aromatase. inhibited Leydig tumor progression, supporting may an important regulator androgen homoeostasis. Further studies are required order establish possible antitumor effects this receptor. Either reactivating or inhibiting expression strategies certain types human