Sedative Drug Withdrawal Seizures: Cellular Eleptrophysiological Mechanisms

摘要: Sedatives of the central nervous system (CNS) are most commonly used, abused, and prescribed drugs. It is now apparent that withdrawal these drugs, particularly if done in a precipitous fashion, can lead to seizures usually generalized. Victor Brausch (1967) demonstrated, large series alcoholics presenting hospital, alcohol was frequently associated with seizures. A more recent study by Hillbom (1980) Finland showed 49% 560 consecutive seizure patients brought hospital emergency room had very history intoxication. Benzodiazepine (Fialip et al., 1987) barbiturate (Fraser 1958) also sometimes There paucity data concerning cellular electrophysiological mechanisms sedative drug Investigations this laboratory over past few years summarized discussed chapter. These studies were performed neurons adult rat or guinea pig hippocampal brain slices, which recorded intracellularly using standard voltage recording techniques (Blaxter 1986) single electrode voltage-clamp for Ca2+ currents 1989).