SENTINEL NODE DETECTION METHOD USING CONTRAST-ENHANCED ULTRASONOGRAPHY WITH SONAZOID IN BREAST CANCER: PRELIMINARY CLINICAL STUDY

摘要: This study aimed to evaluate the usefulness of sentinel lymph node (SLN) detection in breast cancer using contrast-enhanced ultrasonography (CEUS) with subareolar Sonazoid injection. The subjects were 20 patients. General anesthesia was induced and 2 mL injected subareolarly. After massage injection site, axillary area observed transdermally coded phase inversion harmonic mechanical indices 0.15 0.19. When nodes (LNs) seen, they defined as CE-SLN. Two other SLN methods, gamma-probe-guided dye-guided performed together. We evaluated SLNs detected by each method determine if corresponded calculated rate. resected, pathologic examinations done. rate CEUS-guided method, 70%, 75% 100%, respectively. There no statistically significant difference these rates between methods (p = 0.99) but showed a significantly lower than 0.020), also 0.047). number CE-SLNs 1 or (average 1.1) took 5.3) min detect. grossly methods. results indicated metastasis from resected 15 cases. However, 12 cases two remaining five In summary, patients, after Sonazoid, LNs real time ultrasonography. an initial clinical cases, less that method. It is suggested may, some improvements, be useful new modality for identification.