Influence of mydriasis on optical coherence tomography angiography imaging in patients with age-related macular degeneration.

摘要: Purpose To evaluate the effect of topical mydriatic eye drops on optical coherence tomography angiography (OCTA) parameters in patients with age-related macular degeneration (AMD). Methods 27 eyes suffering from AMD were included this cross-sectional study. Patients ≥-4.5 diopters spherical equivalent, corneal opacities or dense cataract preventing high-quality imaging excluded. Whole-en-face scans superficial capillary plexus (SCP) and deep (DCP) central 3x3mm foveal region as well whole-en-face peripapillary radial capillaries (RPC) generated using OCTA (AngioVue®, Optovue). Imaging was first conducted patients’ miosis, then mydriasis after instillation a dilating drop (0.5% tropicamide, 2.5% phenylephrine-HCl). Main outcome measures flow density (FD), avascular zone (FAZ), signal strength index (SSI) motion artifact score (MAS). Results Our results reveal that there is no significant difference between FD measurements taken miosis those around SCP (p = 0.198), DCP 0.458), RPC 0.275) 0.503). Measurements these two states appear to be equivalent for assessment (90%CI within ± 0.05). No found either area FAZ 0.338) SSI 0.371) before tropicamide/phenylephrine. MAS significantly lower application 0.003). Conclusions findings neither nor changed Since improved dilation, examination recommended. Nevertheless, comparison metrics images different pupil (miosis versus mydriasis) valid clinical trials.