The p47phox- and NADPH oxidase organiser 1 (NOXO1)-dependent activation of NADPH oxidase 1 (NOX1) mediates endothelial nitric oxide synthase (eNOS) uncoupling and endothelial dysfunction in a streptozotocin-induced murine model of diabetes
作者： J. Y. Youn , L. Gao , H. Cai
DOI: 10.1007/S00125-012-2557-6
关键词:
摘要: Aims/hypothesis We have previously shown that NADPH oxidase (NOX) lies upstream of uncoupled endothelial nitric oxide synthase (eNOS), which is known to occur in diabetic endothelium. However, it remains unclear specific NOX isoform(s) responsible for eNOS uncoupling and dysfunction mouse models. The aim the present study was test hypothesis one or more mediate(s) eNOS, has been patients with diabetes contribute dysfunction.
springer.com
paperity.org参考文章(33)
David G. Harrison, Endothelial function and oxidant stress. Clinical Cardiology. ,vol. 20, ,(1997) , 10.1002/J.1932-8737.1997.TB00007.X
Tomasz J. Guzik, Shafi Mussa, Daniela Gastaldi, Jerzy Sadowski, Chandi Ratnatunga, Ravi Pillai, Keith M. Channon, Mechanisms of Increased Vascular Superoxide Production in Human Diabetes Mellitus Role of NAD(P)H Oxidase and Endothelial Nitric Oxide Synthase Circulation. ,vol. 105, pp. 1656- 1662 ,(2002) , 10.1161/01.CIR.0000012748.58444.08
K. Chalupsky, H. Cai, Endothelial dihydrofolate reductase: Critical for nitric oxide bioavailability and role in angiotensin II uncoupling of endothelial nitric oxide synthase Proceedings of the National Academy of Sciences. ,vol. 102, pp. 9056- 9061 ,(2005) , 10.1073/PNAS.0409594102
Ian R. Lanza, K. Sreekumaran Nair, Mitochondrial function as a determinant of life span Pflügers Archiv - European Journal of Physiology. ,vol. 459, pp. 277- 289 ,(2010) , 10.1007/S00424-009-0724-5
Hua Cai, Kathy K Griendling, David G Harrison, The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular diseases Trends in Pharmacological Sciences. ,vol. 24, pp. 471- 478 ,(2003) , 10.1016/S0165-6147(03)00233-5
Ulrich Hink, Huige Li, Hanke Mollnau, Mathias Oelze, Edi Matheis, Mark Hartmann, Mikhail Skatchkov, Friedrich Thaiss, Rolf A. K. Stahl, Ascan Warnholtz, Thomas Meinertz, Kathy Griendling, David G. Harrison, Ulrich Forstermann, Thomas Munzel, Mechanisms Underlying Endothelial Dysfunction in Diabetes Mellitus Circulation Research. ,vol. 88, ,(2001) , 10.1161/01.RES.88.2.E14
Mathieu Marella, Byoung Boo Seo, Eiko Nakamaru-Ogiso, J. Timothy Greenamyre, Akemi Matsuno-Yagi, Takao Yagi, Protection by the NDI1 Gene against Neurodegeneration in a Rotenone Rat Model of Parkinson's Disease PLOS ONE. ,vol. 3, ,(2008) , 10.1371/JOURNAL.PONE.0001433
Maria C. Wendt, Andreas Daiber, Andrei L. Kleschyov, Alexander Mülsch, Karsten Sydow, Eberhard Schulz, Kai Chen, John F. Keaney, Bernard Lassègue, Ulrich Walter, Kathy K. Griendling, Thomas Münzel, Differential effects of diabetes on the expression of the gp91phox homologues nox1 and nox4. Free Radical Biology and Medicine. ,vol. 39, pp. 381- 391 ,(2005) , 10.1016/J.FREERADBIOMED.2005.03.020
Jennifer Rivera, Christopher G. Sobey, Anna K. Walduck, Grant R. Drummond, Nox isoforms in vascular pathophysiology: insights from transgenic and knockout mouse models Redox Report. ,vol. 15, pp. 50- 63 ,(2010) , 10.1179/174329210X12650506623401
Guangjie Cheng, J. David Lambeth, NOXO1, regulation of lipid binding, localization, and activation of Nox1 by the Phox homology (PX) domain. Journal of Biological Chemistry. ,vol. 279, pp. 4737- 4742 ,(2004) , 10.1074/JBC.M305968200