MiR-384 inhibits human colorectal cancer metastasis by targeting KRAS and CDC42.

摘要: // Yong-Xia Wang 1, 2, 3, 4, * , Yan-Ru Chen Shan-Shan Liu Ya-Ping Ye 3 Hong-Li Jiao Shu-Yang Zhi-Yuan Xiao Wen-Ting Wei Jun-Feng Qiu Li Liang Liao Yan-Qing Ding 1 Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China 2 School Basic Sciences, Guangdong Province Key Laboratory Molecular Tumor 4 Xinxiang Xinxiang, Henan, These authors have contributed equally to this work Correspondence to: Liao: email: liaowt2002@gmail.com Ding: dyq@fimmu.com Keywords: colorectal cancer, MiR-384, metastasis, KRAS, CDC42 Received: July 20, 2016      Accepted: October 03, Published: 17, 2016 ABSTRACT Colorectal cancer (CRC) is the third most common worldwide. Metastatic progression a primary factor contributing lethality CRC patients. However, molecular mechanisms forming early local invasion and distant metastatic colonies are still unclear present therapeutic approaches for unsatisfactory. Therefore, novel therapies targeting that could prevent tumor spreading recurrence urgently needed. Our study showed decrease miR-384 was found in 83.0% (83/100) And low-leveled expression closely correlated with invasive depth, lymph node metastasis CRC. Overexpression inhibit migrating abilities cells vitro potential vivo . Luciferase assays repressed Kirsten Ras (KRAS) Cell division cycle 42 (CDC42) by directly their 3’-untranslated regions. There functional mechanistic relationship between miRNA-384 our findings suggest miR-384could be potent target Restoration might provide approach reduction metastasis.