Radiotherapy alone in technically operable, medically inoperable, early-stage (I/II) non-small-cell lung cancer.

摘要: Abstract Purpose: To investigate the effectiveness of high-dose, curative radiotherapy (RT) given alone in technically operable, but medically inoperable, patients with early-stage (I–II) non-small-cell lung cancer (NSCLC). Methods and Materials: Computerized manual searches were done to identify published reports dealing RT for NSCLC. Relevant studies identified information provided therein was extracted regarding patient treatment characteristics, outcome, various pretreatment treatment-related factors influencing as well toxicity quality-of-life issues. Results: Although a large variation characteristics noted available studies, median survival time >30 months 5-year rate up 30% had been achieved. Accumulated experience seems suggest that doses at least 65 Gy standard fractionation, or its equivalent when altered fractionation is used, are necessary control Smaller tumors seem have favorable prognosis, issue elective nodal continues be controversial. Analyses patterns failure clearly local predominant pattern. number potential patient- tumor-related prognostic examined, none has shown influence survival. Toxicity usually low, very high (e.g., 80 Gy) conventional approach may carry risk an excessive side effects. Conclusion: High-dose, effective modality