Complement activation in patients at risk of developing the adult respiratory distress syndrome.

摘要: In this prospective study of 50 patients, 36 whom developed the adult respiratory distress syndrome (ARDS), early and intense complement activation was demonstrated. These patients were at risk ARDS because multiple injuries, major abdominal surgery, acute pancreatitis, severe burns, or disseminated intravascular coagulation. Abnormal C3 consumption (as measured by C3d/C3 ratio) elevated plasma C5a-like activity a leukocyte aggregation assay) associated with, respectively, 84 86% cases ARDS. Both tests more sensitive indicators than assays total hemolytic (CH50) C3. The ratio showed close, inverse correlation with CH50 in 47 healthy subjects, increased 12 control after minor surgery. found only ARDS; it highly clinical conditions that predispose to ARDS, but cannot be considered as real predictor occurrence these patients. Sequential samples from both sides pulmonary circulation initial clearance followed release activity. No simultaneous changes levels found, suggesting possible presence modulating factors. observations suggest other factors (e.g., hypoxia metabolic cascades) may influence development