Oligo-2'-deoxyribonucleotides containing uracil modified at the 5-position with linkers ending with guanidinium groups.
作者： Victoria Roig , Ulysse Asseline
DOI: 10.1021/JA029467V
关键词:
摘要: We report here the synthesis and binding studies of oligo-2‘-deoxyribonucleotides (ODNs) containing 2‘-deoxyuridines, modified at 5-position by linkers ending with either one or two guanidinium groups. Comparison was made ODNs 2‘-deoxyuridines amino One were incorporated into pyrimidine strands, their influence on stability duplex (with both DNA RNA targets) triplex structures studied. The strongest stabilization obtained This result confirms that reduction global negative charge number strand is an important parameter in structures.
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sci-hub.se 参考文章(7)
Svetlana O. Doronina, Jean-Paul Behr, Synthesis of 4-guanidinopyrimidine nucleosides for triple helix-mediated guanine and cytosine recognition Tetrahedron Letters. ,vol. 39, pp. 547- 550 ,(1998) , 10.1016/S0040-4039(97)10627-X
Robert O. Dempcy, Kenneth A. Browne, Thomas C. Bruice, Synthesis of the Polycation Thymidyl DNG, Its Fidelity in Binding Polyanionic DNA/RNA, and the Stability and Nature of the Hybrid Complexes Journal of the American Chemical Society. ,vol. 117, pp. 6140- 6141 ,(1995) , 10.1021/JA00127A035
Jordi Robles, Anna Grandas, Enrique Pedroso, Synthesis of modified oligonucleotides containing 4-guanidino-2-pyrimidinone nucleobases Tetrahedron. ,vol. 57, pp. 179- 194 ,(2001) , 10.1016/S0040-4020(00)00991-1
Brendan P. Orner, Xavier Salvatella, Jorge Sánchez Quesada, Javier de Mendoza, Ernest Giralt, Andrew D. Hamilton, De Novo Protein Surface Design: Use of Cation-π Interactions to Enhance Binding between an α-Helical Peptide and a Cationic Molecule in 50 % Aqueous Solution Angewandte Chemie International Edition. ,vol. 41, pp. 117- 119 ,(2002) , 10.1002/1521-3773(20020104)41:1<117::AID-ANIE117>3.0.CO;2-J
Kyung Mi Park, Gary B. Schuster, Photochemistry of 4-substituted (phenylethynyl)triphenyl borate salts: analysis of the visible-region electronic absorption spectra of tetraarylboratirene anions Journal of Organic Chemistry. ,vol. 57, pp. 2502- 2504 ,(1992) , 10.1021/JO00034A060
Christopher J. Wilds, Martin A. Maier, Valentina Tereshko, Muthiah Manoharan, Martin Egli, Direct Observation of a Cytosine Analogue that Forms Five Hydrogen Bonds to Guanosine: Guanidino G-Clamp Angewandte Chemie International Edition. ,vol. 41, pp. 115- 117 ,(2002) , 10.1002/1521-3773(20020104)41:1<115::AID-ANIE115>3.0.CO;2-R
Michael S. Bernatowicz, Youling Wu, Gary R. Matsueda, 1H-Pyrazole-1-carboxamidine hydrochloride an attractive reagent for guanylation of amines and its application to peptide synthesis Journal of Organic Chemistry. ,vol. 57, pp. 2497- 2502 ,(1992) , 10.1021/JO00034A059