The Multifunctional Contribution of FGF Signaling to Cardiac Development, Homeostasis, Disease and Repair

摘要: The current focus on cardiovascular research reflects society's concerns regarding the alarming incidence of cardiac-related diseases and mortality in industrialized world and, notably, an urgent need to combat them by more efficient therapies. To pursue these therapeutic approaches, a comprehensive understanding mechanism action for multifunctional fibroblast growth factor (FGF) signaling biology heart is matter high importance. roles FGFs development range from outflow tract formation proliferation cardiomyocytes chambers. In context cardiac regeneration, 1, 2, 9, 16, 19 21 mediate adaptive responses including restoration contracting rate after myocardial infarction reduction infarct size. However, complications human are correlated with pathogenic effects FGF ligands and/or impairment. 2 23 involved maladaptive such as hypertrophic, fibrotic failure. Among known causative (FGFs 23) or protective 15/19, 16 21) diseases, display diagnostic potential. effective role induction progenitor stem cells during has been employed boost limited capacity postnatal repair. renew replenish damaged cardiomyocytes, 10 were tested (induced-) pluripotent cell-based approaches stimulation cell cycle re-entry adult cardiomyocytes. This review will shed light wide beneficiary detrimental actions mediated their receptors heart, which may open new avenues ameliorating complications.