Metabolic basis of primary hypercholesterolemia.
作者： G L Vega , M A Denke , S M Grundy
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摘要: BACKGROUNDHypercholesterolemia is a well-established risk factor for coronary heart disease. However, the mechanisms underlying hypercholesterolemia, elevated low density lipoprotein (LDL) in particular, are not well understood. To determine these mechanisms, we studied LDL kinetics group of men with primary hypercholesterolemia.METHODS AND RESULTSLDL 134 middle-aged high-risk levels cholesterol (more than 160 mg/dl) were compared 16 borderline (120-159 and 14 heterozygous familial hypercholesterolemia (FH). Patients (non-FH) further divided into moderate (LDL cholesterol, 160-210 mg/dl; n = 108) severe groups more 210 26). Four factors contributed to increasing concentrations above range moderately levels: 37 patients had no increase in...
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