Polymorphonuclear leukocytes in acute inflammation

摘要: The normal function of the professional phagocytes — polymorphonuclear leukocytes (PMN), monocytes, macrophages and eosinophils is to protect individual from microbial infection by seeking out destroying invading microbes. In order perform this effectively phagocyte must move towards sites infection, recognize, phagocytose, kill digest microbe and, if necessary, recruit other cells assist. These phagocytic possess a membrane-bound enzyme system which can be activated produce toxic oxygen radicals in response wide variety stimuli. purpose destroy microbes, parasites or tumours directing against target cells. Whilst beneficial effects these well known, it has become clear that inappropriate production have severe deleterious diseases such as Behcet’s disease, dermatitis herpetiformis, mucocutano-lymph node syndrome, rheumatoid arthritis, crystal-induced arthropathies, systemic lupus erythematosus, colitis ulcerosa, Crohn’s adult respiratory distress reperfusion injury carcinogenesis. chapter we shall concentrate on properties radical generating system, its activation biological products.