Short-term variability of blood pressure and heart rate in Guillain-Barré syndrome without respiratory failure.

摘要: The effect of Guillain-Barre syndrome (GBS) on the short-term variability blood pressure and heart rate was evaluated in six patients presenting with a moderate form syndrome, i.e. unable to stand up unaided without respiratory failure, at height disease during recovery. were compared age-matched healthy volunteers. During acute phase GBS exhibited significant elevation (+26 beats/min subjects), but acceleratory response atropine, or 60 degrees head-up tilt, maintained. Resting plasma noradrenaline levels high GBS, secretory tilt preserved. Desensitization observed reduced pressor action this alpha-adrenoceptor agonist. Blood normal did not induce orthostatic hypotension GBS. Power spectral analysis demonstrated marked alterations cardiovascular variability. overall period markedly reduction predominantly high-frequency (respiratory) range (-73%). low-frequency component also (-54%). This profile could result from demyelination reflex loop controlling oscillations desensitization arterial tree an elevated noradrenaline. Sympathetic nervous activation may contribute resting