Defective Plasma Antioxidant Defenses and Enhanced Susceptibility to Lipid Peroxidation in Uncomplicated IDDM

摘要: Oxidative stress is postulated to be increased in patients with IDDM. Accumulating evidence suggests that oxidative cell injury caused by free radicals contributes the development of IDDM complications. On other side, a decreased efficiency antioxidant defenses (both enzymatic and nonenzymatic) seems correlate severity pathological tissue changes Thus, we determined plasma defenses, measuring total radical-trapping capacity (TRAP) two markers stress, lipid hydroperoxides (ROOHs) conjugated dienes, 72 well-controlled without evident complications, compared 45 nondiabetic subjects. Compared control subjects, showed significantly reduced TRAP (669 +/- 131 vs. 955 104 micromol/l, P < 0.001) levels ROOHs (7.13 2.11 2.10 0.71 dienes (0.0368 0.0027 0.0328 0.0023 arbitrary units [AU], 0.01), especially trans-trans conformation (0.0340 0.0028 0.0259 0.0022 AU, 0.001), concurrent reduction cis-trans (0.0028 0.0011 0.0069 0.0012 0.001). The parameters studied did not appear correlated metabolic (HbA1c levels) profile (cholesterol or triglyceride levels). ROOH diene levels, together ratio cis-trans/trans-trans which reflects an altered redox status plasma, indicate patients, enhanced are defective, regardless diabetes duration, control, presence