Neural crest cell formation and migration in the developing embryo.

摘要: Neural crest cells arise from the neural tube shortly after its closure and migrate extensively through prescribed regions of embryos, where they differentiate into most peripheral nervous system as well facial skeleton pigment cells. Along embryonic axis, several distinct populations differ both in their migratory pathways range derivatives. Whereas those arising midbrain a uniform sheet cells, emerging hindbrain trunk segmented manner. For example, move preferentially rostral, but not caudal, half each somite. Interactions with tissues encountered during migration strongly influence this segmental pattern. mesodermal somites dictate otic placode appears to attract Although little is known about molecular basis underlying migration, patterns gene expression are thought contribute arrangement Furthermore, possess integrin receptors that may be important for interacting extracellular matrix molecules surroundings.