Clinical features and outcomes in 348 patients with polyarteritis nodosa: a systematic retrospective study of patients diagnosed between 1963 and 2005 and entered into the French Vasculitis Study Group Database

摘要: Objective Previous studies of polyarteritis nodosa (PAN) included patients with microscopic polyangiitis, because these entities were not distinguished prior to the Chapel Hill Consensus Conference (CHCC). This study was undertaken describe main characteristics and long-term outcomes in well-characterized PAN diagnoses. Methods We conducted a systematic retrospective 348 who diagnosed as having between March 1963 October 2005, registered French Vasculitis Study Group database, satisfied American College Rheumatology CHCC criteria. Patient analyzed compared according hepatitis B virus (HBV) status. Results At diagnosis, mean +/- SD age 51.2 17.3 years. The most frequent findings general symptoms (93.1%), neurologic manifestations (79%), skin involvement (49.7%), abdominal pain (35.6%), hypertension (34.8%); 66.2% had renal artery microaneurysms; 70.1% histologically proven PAN. Patients HBV-related (n = 123) more peripheral neuropathy, pain, cardiomyopathy, orchitis, non-HBV-related 225). During followup 68.3 63.5 months, 76 (21.8%) relapsed (63 [28%] versus 13 [10.6%]; P 65 years, hypertension, gastrointestinal requiring surgery or at least consultation surgeon independent predictors death, whereas cutaneous higher risk relapse. Conclusion Our indicate that rate mortality from remains high, especially for elderly, relapses do occur, particularly manifestations.