Mitogen-Activated Protein Kinases in Mammalian Oxidative Stress Responses
作者： Christopher Runchel , Atsushi Matsuzawa , Hidenori Ichijo
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摘要: Abstract All aerobic organisms are exposed to oxidative stress during their lifetime and required respond appropriately for maintenance of survival homeostasis. Sustained exposure has devastating effects in organisms, and, not surprisingly, been implicated numerous human diseases. Therefore, an understanding how mammals is crucial both biologically clinically. Intracellular signaling pathways, which activated response excessive oxygen radicals, play essential roles overcoming stress. The mitogen-activated protein kinase (MAPK) pathways involved diverse physiological processes, critical induction responses. In this review, we will discuss the MAPKs stress, upstream leading MAPK activation, regulation, downstream substrates, with a focus on mammalian systems. Ant...
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