Variability at the uridine diphosphate glucuronosyltransferase 1A1 promoter in human populations and primates.

摘要: Variation at the UDP-glucuronosyltransferase (UGT) 1A1 gene promoter is present in humans. Variable numbers of TA repeats TATA box this are found which inversely related to levels expression. We investigated polymorphism 658 individuals from a worldwide sample 15 aboriginal and two admixed human populations. This study shows that there great deal variability across ethnic groups with regard UGT1A1 allele frequencies, most common varying frequency 33% 91%. Populations African origin harbor four different alleles while non-African populations appear have only alleles. In addition, associated lower expression reach highest frequencies lowest among Asians Amerindians. Thus, more metabolism drugs eliminated by glucuronidation should be expected Sub-Saharan origin. The sequence analysis nine primate species number has increased during evolution achieving largest suggest does not reflect historical relationships between it may maintained natural selection. Our findings consistent proposal repeat variation balanced polymorphism.