Group II metabotropic glutamate receptor agonists as a potential drug for schizophrenia.

摘要: Metabotropic glutamate receptors (mGlu receptors), with their unique signaling systems and pharmacological characteristics, have emerged as a new topic in excitatory amino acid research. Among them, the distribution of group II mGlu receptors, such mGlu(2) mGlu(3) involvement these regulation neurotransmission are particularly interesting. Recently, potent agonists for mGlu(2/3) receptor been synthesized, roles intensively investigated using animal models. clearly crucial central nervous system, accumulating evidence both rodents human studies has suggested that may be beneficial treatment psychiatric disorders schizophrenia. Possible neuronal circuits through which exert effects also investigated.