Synthesis and pharmacokinetics of thiacoccide labeled with tritium
作者： A. D. Shestakov , Yu. L. Kaminskii , I. M. Nurova , V. N. Nikitina , V. I. Zaionts
DOI: 10.1007/BF00833348
关键词:
摘要: To obtain information on the pharmacokinetics of thiacoccide, authors effect synthesis an analog viz., hydrochloride 2-methyl-N-(2'-n-propyl-4'-aminopyrimid-5'-ylmethyl)pyridinium chloride (I) labeled with tritium. The simplest way to introduce a tritium label into is by isotopic exchange hydrogen H/sup 3/HO. Typical material obtained from water shown. dynamics /sup 3/H distribution in organism chick and rate its elimination single administration thiacoccide containing isotope both methyl group pyridine ring are
springer.com
sci-hub.se 参考文章(10)
Y Yoshioka, Y Kawazoe, M Onishi, Studies on Hydrogen-Abstracting Reactions. I. Deuteration of Pyridines and Pyridazines Chemical & Pharmaceutical Bulletin. ,vol. 12, pp. 1384- 1386 ,(1964)
Martin Negwer, Organisch-chemische Arzneimittel und ihre Synonyma Akademie. ,(1978)
Akira Takamizawa, Kentaro Hirai, Studies on the Pyrimidine Derivatives. XXVII. Reactions of Amidines with 3-Ethoxy-2-methoxymethylenepropionitrile, 3-Ethoxy-2-ethoxymethoxymethyl-propionitrile, Ethyl 3-Ethoxy-2-methoxymethylenepropionate, and Ethyl 3-Ethoxy-2-ethoxymethoxymethylpropionate. CHEMICAL & PHARMACEUTICAL BULLETIN. ,vol. 12, pp. 393- 397 ,(1964) , 10.1248/CPB.12.393
L. Reio, Paper chromatographic separation and identification of phenol derivatives and related compounds of biochemical interest using a reference system Journal of Chromatography A. ,vol. 88, pp. 119- 147 ,(1974) , 10.1016/S0021-9673(01)91778-9
S.R. Watkins, H.F. Walton, Absorption of amines on cation exchange resins Analytica Chimica Acta. ,vol. 24, pp. 334- 342 ,(1961) , 10.1016/0003-2670(61)80066-4
Yutaka Kawazoe, Masako Ohnishi, Yuko Yoshioka, Studies on hydrogen exchange. VI. The base-catalyzed hydrogen exchange of alpha-hydrogens in alkyl groups substituted on some nitrogen-containing heteroaromatic rings. Chemical & Pharmaceutical Bulletin. ,vol. 15, pp. 1225- 1231 ,(1967) , 10.1248/CPB.15.1225
H. U. von Daeniker, Der Nachweis kleiner Mangen Picoline mit Hilfe von Ultraviolett- und Infrarot-Absorptionesspektren Helvetica Chimica Acta. ,vol. 35, pp. 1955- 1957 ,(1952) , 10.1002/HLCA.19520350623
L. van der Does, H. J. den Hertog, Bromination of methylpyridines in fuming sulfuric acid Recueil des Travaux Chimiques des Pays-Bas. ,vol. 84, pp. 951- 964 ,(2010) , 10.1002/RECL.19650840715
Bernard Kramer, Isolation from human urine and preliminary characterization of a metabolite of “pyridine-2-aldoxime methiodide” Biochemical Pharmacology. ,vol. 11, pp. 299- 305 ,(1962) , 10.1016/0006-2952(62)90052-7
Herbert C. Brown, Xavier R. Mihm, Steric Effects in Displacement Reactions. III. The Base Strengths of Pyridine, 2,6-Lutidine and the Monoalkylpyridines Journal of the American Chemical Society. ,vol. 77, pp. 1723- 1726 ,(1955) , 10.1021/JA01612A002