Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells.
作者： Zhihua Song , Jun Cai , Yanxia Liu , Dongxin Zhao , Jun Yong
DOI: 10.1038/CR.2009.107
关键词:
摘要: Human induced pluripotent stem (iPS) cells are similar to embryonic (ES) cells, and can proliferate intensively differentiate into a variety of cell types. However, the hepatic differentiation human iPS has not yet been reported. In this report, were by stepwise protocol. The expression liver markers liver-related functions cell-derived monitored compared with that differentiated ES primary hepatocytes. Approximately 60% at day 7 expressed alpha fetoprotein Alb. 21 exhibited including albumin Asecretion, glycogen synthesis, urea production inducible cytochrome P450 activity. comparable cells. These results show which be efficiently hepatocyte-like
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