3,4-substituted piperidine derivatives as renin inhibitors

作者: Patrick Lacombe , Sebastien Laliberte , Dwight Macdonald , Austin Chih-Yu Chen , Erich L. Grimm

DOI:

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摘要: The present invention relates to 3,4-substituted piperidinyl-based renin inhibitor compounds bearing at 4-position oxopyridine and having the formula (I). further pharmaceutical compositions containing said compounds, as well their use in treating cardiovascular events renal insufficiency.

参考文章(55)
Vincenzo Tschinke, Peter Herold, Aleksandar Stojanovic, Nathalie Jotterand, Christoph Schumacher, Dirk Behnke, Robert Mah, Stefan Stutz, 3,4,5-Substituted piperidines as therapeutic compounds ,(2007)
Piero del Soldato, Antithrombotic organic nitrates ,(1997)
Atsuko Nihonyanagi, Keiichi Masuya, Takanori Kanazawa, Osamu Irie, Atsushi Toyao, 3,4,(5)-substituted tetrahvdropyridines ,(2006)
Corinna Grisostomi, Lubos Remen, Thomas Weller, Olivier Corminboeuf, Olivier Bezencon, Daniel Bur, Sylvia Richard-Bildstein, Primary amines as renin inhibitors ,(2007)
Corinna Grisostomi, Lubos Remen, Thomas Weller, Olivier Corminboeuf, Olivier Bezencon, Daniel Bur, Sylvia Richard-Bildstein, Dwight Macdonald, John Scheigetz, Dan Mckay, David Powell, Michel Therien, Daniel Dube, Secondary Amines as Renin Inhibitors ,(2007)
Piero del Soldato, Ace-inhibitor nitric salts ,(1998)
Lubos Remen, Thierry Sifferlen, Thomas Weller, Daniel Bur, Sylvia Richard-Bildstein, Walter Fischli, Olivier Bezencon, 9-azabicyclo[3.3.1]non-6-ene derivatives with a heteroatom at the 3-position as renin inhibitors ,(2004)
Lubos Remen, Thomas Weller, Olivier Bezencon, Daniel Bur, Sylvia Richard-Bildstein, Walter Fischli, Novel tetrahydropyridine derivatives as renin inhibitors ,(2003)
Daniel Dale Holsworth, Noe Erasga, Jeremy John Edmunds, Xue-Min Cheng, Noel Aaron Powell, Wayne Livingston Cody, Chitase Lee, Piperidine derivatives as renin inhibitors for the treatment of hypertension ,(2004)
Richard C. Larock, Reagents for Organic Synthesis ,(1967)