Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide

作者: J. Lu , E.-H. Chew , A. Holmgren

DOI: 10.1073/PNAS.0701549104

关键词:

摘要: … In contrast, in our in vitro study, in the presence of 1 mM GSH (mimicking the intracellular GSH levels), the Trx system was inhibited by ATO doses 0.5 μM (Fig. 4A). Furthermore, cell …

参考文章(69)
Yongkui Jing, Jie Dai, Ruth M.E. Chalmers-Redman, Willam G. Tatton, Samuel Waxman, Arsenic Trioxide Selectively Induces Acute Promyelocytic Leukemia Cell Apoptosis Via a Hydrogen Peroxide-Dependent Pathway Blood. ,vol. 94, pp. 2102- 2111 ,(1999) , 10.1182/BLOOD.V94.6.2102
A Holmgren, Thioredoxin and glutaredoxin systems Journal of Biological Chemistry. ,vol. 264, pp. 13963- 13966 ,(1989) , 10.1016/S0021-9258(18)71625-6
Ryan H Engel, Andrew M Evens, Oxidative stress and apoptosis: a new treatment paradigm in cancer Frontiers in Bioscience. ,vol. 11, pp. 300- 312 ,(2006) , 10.2741/1798
Hiroshi Tanaka, Hirofumi Arakawa, Tatsuya Yamaguchi, Kenji Shiraishi, Seisuke Fukuda, Kuniko Matsui, Yoshiki Takei, Yusuke Nakamura, A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage Nature. ,vol. 404, pp. 42- 49 ,(2000) , 10.1038/35003506
Robert Wagner, Miroslav Radman, Mismatch Binding Protein-Based Mutation Detection Systems Methods. ,vol. 7, pp. 199- 203 ,(1995) , 10.1006/METH.1995.1025
Norihiko Kondo, Hajime Nakamura, Hiroshi Masutani, Junji Yodoi, Redox regulation of human thioredoxin network. Antioxidants & Redox Signaling. ,vol. 8, pp. 1881- 1890 ,(2006) , 10.1089/ARS.2006.8.1881
Masao Saitoh, Hideki Nishitoh, Makiko Fujii, Kohsuke Takeda, Kei Tobiume, Yasuhiro Sawada, Masahiro Kawabata, Kohei Miyazono, Hidenori Ichijo, Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. The EMBO Journal. ,vol. 17, pp. 2596- 2606 ,(1998) , 10.1093/EMBOJ/17.9.2596