Cosmos 1887 mission overview: effects of microgravity on rat body and adrenal weights and plasma constituents

摘要: The Cosmos 1887 biosatellite carried 10 male rats and 2 rhesus monkeys on its 12.5-day mission. Upon re-entry the Vostok vehicle overshot designated landing site, which resulted in fasting of animals for 42 h, exposure to cage temperatures 12-15 degrees C, days delay death rats. No overt untoward effects delayed recovery were apparent. Tissues from harvested by Soviet scientists, appropriately preserved, provided U.S. investigators. Flight grew more slowly had larger adrenal glands than earth gravity controls. Analysis plasma revealed increased concentrations hepatic alkaline phosphatase, glucose, urea nitrogen, creatinine flight In contrast, electrolytes, total protein, albumin, corticosterone, prolactin, immunoreactive growth hormone levels unchanged. However, testosterone concentration was marginally decreased after thyroid suggestive reduced function. Due possibl...