Enrichment of target sequences for next-generation sequencing applications in research and diagnostics
作者： Janine Altmüller , Birgit S. Budde , Peter Nürnberg
关键词:
摘要: Abstract Targeted re-sequencing such as gene panel sequencing (GPS) has become very popular in medical genetics, both for research projects and diagnostic settings. The technical principles of the different enrichment methods have been reviewed several times before; however, new products are constantly entering market, researchers often puzzled about requirement to take decisions long-term commitments, product technology. This review summarizes important considerations experimental design provides helpful recommendations choosing best strategy various applications.
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