The Dorsal Mesenchymal Protrusion and the Pathogenesis of Atrioventricular Septal Defects.
作者： Tara Burns , Yanping Yang , Emilye Hiriart , Andy Wessels
DOI: 10.3390/JCDD3040029
关键词:
摘要: Congenital heart malformations are the most common type of defects found at birth. About 1% infants born with one or more defect on a yearly basis. Heart Disease (CHD) causes deaths in first year life than any other congenital abnormality, and each year, nearly twice as many children die United States from CHD all forms childhood cancers combined. Atrioventricular septal (AVSD) affecting approximately 1 2000 live births. Babies an AVSD often require surgical intervention shortly after However, even successful surgery, these individuals typically have to deal lifelong complications being leaky mitral valve. In recent years understanding molecular etiology morphological mechanisms associated pathogenesis AVSDs has significantly changed. Specifically, studies linked abnormal development Dorsal Mesenchymal Protrusion (DMP), Second Field-derived structure, this defect. review we will be discuss some latest insights into role DMP normal formation atrioventricular complex AVSDs.
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