Effects of a new advanced glycation inhibitor, LR-90, on mitigating arterial stiffening and improving arterial elasticity and compliance in a diabetic rat model: aortic impedance analysis.

摘要: Background and Purpose We determined the effects of treatment with LR-90, an inhibitor advanced glycation end products, on mechanical properties arterial system in streptozotocin (STZ)-induced diabetic Sprague Dawley rats, using aortic impedance analysis, further investigated LR-90 progression pathology. Experimental Approach STZ-induced rats were treated or without (50 mg L-1 drinking water) for 8 weeks compared control groups. Arterial BP measurements, various metabolic parameters, histopathology, collagen cross-linking, AGE accumulation, RAGE protein expression tissue determined. Pulsatile parameters evaluated a standard Fourier series expansion technique impulse response function filtered input spectra. Key Results LR-90 reduced glycated haemoglobin triglycerides levels, although it had no effect glycaemic status. did not affect BP, but prevented diabetes-induced increase peripheral resistance variations distensibility, as characteristic by 21%. also elevation wave reflection factor, indicated 22.5% reduction associated 23.5% transit time, suggesting prevents augmentation systolic load left ventricle. Moreover, inhibited cross-linking accumulation vasculature rats. Conclusions Implications Treatment may impart significant protection against stiffening cardiac hypertrophy provides additional therapeutic option complications.