New achievements and pharmacotherapeutic approaches to impotence in the elderly.

摘要: Erectile dysfunction (ED) has a negative impact on the qualify of life elderly men, but impotence is not an absolute concomitant aging. Aging changes influencing sexual function in men consist decreased capacity to reach arousal by imagination or view, fragility erection, and increase refractory period. These events may be part andropause syndrome, which includes decrease intellectual activity, fatigue, depression, decreases body hair, lean mass bone mineral density, accompanied weight. As consequence, overlap aging processes, concurrent diseases social situations are subject, results great variability reported epidemiological studies. In same way, complex physiology erection depends social, environmental, physical context it occurs. New achievements research intracellular mechanisms neuroendocrinology contribute better understanding patho-physiology ED elderly. For example, testosterone declines with age interindividual variability, since other hormonal also involved. What currently can easily identified alteration LH-testosterone feedback alterations, although hormone levels fall normal range. Nevertheless, extent age-dependent decline hormones leads health problems that affect quality remains clarified. Several concepts aging-related processes have been challenged, conditions were once accepted as physiologically age-related now thought lead medical problems, until erectile underreported, underdiagnosed, undertreated, especially Nowadays, we witnessing rapid growth available pharmacotherapies, from intracavernous injections vasoactive drugs, powerful new oral agents, differing pharmacological dynamic kinetic properties. options for treatment therefore possible, taking into account both possibility changing ineffective drugs augmenting efficacy means synergistic associations. This rich generation progress certainly contributing approach sexuality people.