Homozygosity for an Alpha-Adducin Polymorphism (460TRP) Is Associated with Salt-Sensitivity and Low-Renin Hypertension in Humans

摘要: P133 Single nucleotide polymorphisms of the adducin genes have been associated with development elevated blood pressure in rat. However, previous studies 460Trp polymorphism human alpha-adducin not clearly identified an association hypertension. In this study, 281 hypertensive subjects were subgrouped by intermediate phenotypes plasma renin status and sensitivity systolic to dietary sodium. The frequency allele was 19% 9 (3.2%) homozygous (TT) for allele. response changes sodium (>150 meq/d vs. ≤30 meq/d) significantly (p