Furosemide absorption in patients with cirrhosis

摘要: Twelve patients with cirrhosis (seven mild and five severe) were administered intravenous oral furosemide in random order to assess its absorption disposition. Total serum clearance (113 ± 49 ml/min), volume of distribution (11.9 4.5 L), elimination half-life (166 149 minutes) similar those reported previously both healthy control subjects cirrhosis. Bio-availability 58% 17% (range, 37% 82%) was comparable that previous studies, there no difference between severe In 9 12 the mean time longer than residence determined after administration (mean for all patients, 203 86 versus 134 ±101 minutes; p < 0.05), indicating followed a “flip-flop” model these patients. prolonged relative normal irrespective presence edema. As such, slower edematous states, such as congestive heart failure cirrhosis, does not appear be consequence edema per se. Moreover, because changes occur failure, it seems diseases diverse pathophysiology can slow absorption. Clinical Pharmacology Therapeutics (1991) 49, 241–247; doi:10.1038/clpt.1991.23