The Neural Basis of Working Memory: Evidence from Neuropsychological, Pharmacological and Neuroimaging Studies

摘要: Studies with multiple methods, including behavioral, neuroimaging and pharmacological studies of healthy brain damaged patients, have been used to provide converging evidence for the role PFC in cognition. One process thought be subserved by PFC, executive function, remains difficult characterize, but progress is being made. The physiological basis this as well other processes (such working memory) are beginning mapped out, both on a neuroanatomical neurochemical level. An improved understanding function will make an important contribution our goal normal human brain. It also impact using knowledge improve care patients damage region. Although many individuals frontal lobe pathology perform standard neuropsychological tests, they often exhibit significant functional difficulties (Eslinger & Damasio, 1985; Shallice Burgess, 1991). These practical difficulties, which seem caused cognitive deficits organization, planning, integration, likely due impairments investigated studies. Because incomplete recovery prefrontal prevents full re-integration into society, development more effective treatment approaches these such intervention, extremely component their care. Thus, findings foundation potential therapies that may not only damage, decrease disability associated those impairments.