Differences between Measured Total Nitrogen Losses in Spent Peritoneal Dialysate Effluent and Estimated Nitrogen Losses

摘要: Objective Patients treated by peritoneal dialysis (PD) are at increased risk of muscle wasting, and clinical guidelines recommend assessing dietary intake, calculating protein equivalent nitrogen appearance (PNA) to assure sufficiency. The PNA equations were developed many years ago, we wished re-evaluate them comparing estimated measured losses. Design Methods This is a cross-sectional observational cohort study. study setting was an outpatient PD center university hospital the subjects included 67 patients undergoing PD, in which 61.2% males, median age 67.3 (53.2-79.4) years. content 24-hour spent dialysate automated chemiluminescence analyzer compared with estimates losses based on urea loss using Bergstrom, Randerson, Blumenkrantz equations. Results Measured total more than equivalent, 5.79 ± 4.07 versus 2.66 1.67 g/day (P  Conclusion Our findings demonstrate that higher losses, currently used predictive underestimate amount lost. It important attempt compensate iatrogenic recommending appropriate intake patients, minimize wasting. discrepancy may have arisen because characteristics newer prescriptions change patient demographics. We propose new equation = 0.31 × (urea mmol) + 7.17, which will require prospective validation additional studies.